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On-site NCBI Bioinformatics Workshop at Yale School of Medicine

February 24, 2016 - 2:00pm by Rolando Garcia-Milian

On April 5 and 6, Dr. Peter Cooper*** will provide training in the form of four workshops (see below) on the some of the most valuable National Center for Biotechnology Information bioinformatics resources and tools at Yale School of Medicine. This training is hosted by the Yale Cushing/Whitney Medical Library. Although free and open to any Yale affiliate, it is recommended to register since seating is limited.   Please contact Rolando Milian for questions on these sessions: 203-785-6194   A Practical Guide to NCBI BLAST   This workshop highlights important features and demonstrates the practical aspects of using the NCBI BLAST service, the most popular sequence similarity service in the world. You will learn about useful but under-used features of the service. These include access from the Entrez sequence databases; the new genome BLAST service quick finder; the integration and expansion of Align-2-Sequences; organism limits and other filters; re-organized databases; formatting options and downloading options; and TreeView displays. You will also learn how to use other important sequence analysis services associated with BLAST including Primer BLAST, an oligonucleotide primer designer and specificity checker; the multiple protein sequence alignment tool, COBALT; IgBLAST, a tool for analysis of antibody and T-cell receptor sequences; and MOLE-BLAST, a new tool for clustering and providing taxonomic context for targeted loci sequences (16S, ITS, 28S). These aspects of BLAST provide easier access and results that are more comprehensive and easier to interpret. Date:                     Tuesday, April 5, 2016 Time:                     9:00am - 12:00pm Location:              C-103 - SHM 333 Cedar St, New Haven CT 0652   Accessing Genomes, Assemblies and Annotation Products   You will learn how NCBI processes genome-level data and produces annotation through the prokaryotic and eukaryotic genome annotation pipelines. You will find, browse, and download genome-level data for your organism of interest and for environmental and organismal metagenomes using the Genome, BioProject and Assembly resources. In addition to assembled and annotated data, you will retrieve and download draft whole genome shotgun and read-level next-gen sequencing data from the Nucleotide and Sequence Read Archive (SRA) databases. You will access results of precomputed analyses of genomes, as well as perform your own analyses of assembled and unassembled genomic data using NCBI's genome BLAST and SRA-BLAST services. Date:                     Tuesday, April 5, 2016 Time:                     1:30pm - 4:00pm Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520   Accessing NCBI Human Variation and Medical Genetics Resources   You will learn to use and access resources associated with human sequence variations and phenotypes associated with specific human genes and phenotypes. The workshop will emphasize the Gene, MedGen and ClinVar resources to search by gene, phenotype and and variant respectively. You will learn how to map variation from dbSNP and dbVAR onto genes, transcripts, proteins, and genomic regions and how to find genetic tests in GTR. You will also gain experience using additional tools and viewers including PheGenI, a browser for genotype associations and the new Variation Viewer the 1000 Genomes Browser, which provide a useful ways to search for, map and browse variants as well as upload and download data in genomic context. Date:                     Wednesday, April 6, 2016 Time:                     9:00am - 12:00pm Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520   Exploring Gene Expression Information at the NCBI   You will find, display and analyze microarray and sequence-based expression data that are stored in the Gene Expression Omnibus (GEO), Sequence Read Archive (SRA), UniGene, and Epigenomics databases to investigate the potential for expression of transcript splice variants and examine the levels of expression under varied experimental conditions as well as in different tissues and disease states. You will analyze Microarray data the on-demand GEO2R tool and will explore the precomputed transcript analyses that are displayed on the UniGene and GEO Profiles pages. You will explore genome-aligned RNA-Seq data through the Gene database's sequence viewer displays and analyze raw RNA-Seq reads in the SRA database using NCBI's SRA-BLAST service. Date:                     Wednesday, April 6, 2016 Time:                     1:30pm - 4:00pm Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520 ***Dr. Peter Cooper, Staff Scientist, National Center for Biotechnology Information (NCBI) directs the scientific outreach and training program for the National Center for Biotechnology Information at the National Library of Medicine. Peter has conducted and developed training courses for biologists in the use of NBCI molecular databases and has provided scientific user support for the NCBI since 1998. Prior to joining the NCBI Peter pursued diverse biological research interests including peptide neurochemistry, marine environmental toxicology, and taught biology and chemistry. Peter earned a BS from Virginia Tech, a MA in chemistry from the Johns Hopkins University and a Ph.D. in Marine Science from the College of William and Mary, School of Marine Science in 1996

75 Years of Cushing/Whitney Medical Library: The Rotunda

February 16, 2016 - 9:52am by Andy Hickner

(By Melissa Grafe)     Walk past the Circulation desk at the entrance of the Cushing/Whitney Medical Library and down the corridor displaying art from the Prints, Drawings, and Posters collection. Coming out of the corridor, you enter the Rotunda, the heart of the library.  The Rotunda of the Medical Library honors famed neurosurgeon and bibliophile Dr. Harvey Cushing (1869-1939).  When Cushing, along with Yale physiologist John Fulton and Swiss tuberculosis expert Arnold Klebs, joined their collections together, Cushing successfully advocated for a medical library at Yale. Grosvenor Atterbury, Cushing's classmate and friend since college, was selected as the architect, and brought “into reality Dr. Cushing’s dream of a great medical library.”  Designed in a Y, at the center of the library is the Rotunda, the gift of Cushing's Class of 1891, which was celebrating its 50th reunion.  Inscribed on one side of the Rotunda:   The Class of Yale 1891 Have Contributed to this Rotunda In Affectionate Memory of Their Classmate HARVEY CUSHING Born in Cleveland Ohio, 8 April 1869 Died in New Haven Connecticut, 7 October 1939   The words below the balcony read: This Rotunda is Dedicated to Harvey Cushing—Inspiring Teacher—Pathfinder in Neurosurgery —Master of the Science and Art of Healing   The crests just below the balcony are of 14 universities that awarded Cushing honorary degrees, including Oxford University and the University of Edinburgh. Eight exhibition cases showcased the Medical Historical Library’s collections, topics in medicine and medical history, and the history of the Medical School for nearly 75 years.  Medical students, faculty, researchers, alumni, and visitors since 1941 have crossed the grand seal on the floor, which incorporates parts of the seal of Yale University with a simple map of the Medical Library.  Many have also stood in the center of the seal and yelled out to experience the strange acoustics resulting from the design of the Rotunda and the colorful skylight directly above the seal.   For the Medical Library’s 75th anniversary, please consider giving towards the Rotunda’s restoration or other 75th anniversary projects.

Embase: A strong source for international and drug literature

February 4, 2016 - 10:33am by Andy Hickner

Embase is a database covering international biomedical literature from 1974 to the present. All MEDLINE records are included in Embase, as well as over 5 million records not covered in MEDLINE.  Embase is especially strong in its coverage of drug therapy, pharmaceutical research, and medical devices. Embase also provides a global perspective in medicine, with coverage of journals published in 90 countries.  For Embase training or help, contact your personal librarian or your departmental librarian. 

Training Sessions for the Winter Semester at the Cushing/Whitney Medical Library

January 29, 2016 - 3:41pm by Andy Hickner

The Cushing/Whitney Medical Library has prepared the following menu of training sessions for the winter semester. It includes training on how to do literature search, patent search, use of Cytoscape, genome browsers, EndNote, systematic reviews, functional analysis, variant annotation, and more. Since seating is limited, please register to reserve yours by following the links next to each session. Please contact Vermetha Polite vermetha.polite@yale.edu for questions or comments on these sessions. PubMed: Improve your Skills Description:        PubMed is one of the most comprehensive resources for searching the biomedical literature.  Most researchers have used it at one time or another, but it may be time to brush up on your search skills to ensure that you a relevant set of results.  In this class, we will go over PubMed search techniques, including how to quickly limit a search and the role of Medical Subject Headings (MeSH) in creating more effective searches. Participants will also learn timesaving features such as saving searches and how to link out to full-text. Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Date & Time:      5:00pm - 5:50pm, Thursday, February 4, 2016 Date & Time:      5:00pm - 5:50pm, Thursday, February 18, 2016 Date & Time:      12:00pm - 12:50pm, Friday, February 26, 2016 Date & Time:      5:00pm - 6:00pm, Wednesday, March 2, 2016 Date & Time:      5:00pm - 5:50pm, Tuesday, March 22, 2016 Date & Time:      5:00pm - 5:50pm, Wednesday, April 13, 2016   RefWorks Basics Description:        Learn basic features and use of this web-based citation management system, such as setting up a Yale account (no purchase required), exporting citations from external databases and importing them into your account, and using RefWorks with MS Word to create citations in context and bibliographies for your manuscripts. This class is one hour. Date & Time:      12:00pm - 1:00pm, Wednesday, January 27, 2016 Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Managing your References with EndNote Description:        EndNote is a citation-management software application that makes saving citations and then citing them within documents easy. EndNote's pre-formatted style templates, specific to journal instructions, make it easy to insert references into your papers as you write them. In this class you will learn how to easily add citations into your EndNote library, attach PDFs, and insert references into your research papers. Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Date & Time:      3:00pm - 4:00pm, Thursday, January 21, 2016 Date & Time:      5:00pm - 6:00pm, Wednesday, January 27, 2016 Date & Time:      2:00pm - 3:00pm, Friday, February 5, 2016 Date & Time:      5:00pm - 6:00pm, Wednesday, February 10, 2016 Date & Time:      5:00pm - 6:00pm, Wednesday, February 24, 2016 Date & Time:      5:00pm - 6:00pm, Tuesday, March 8, 2016 Date & Time:      2:00pm - 3:00pm, Wednesday, March 16, 2016 Date & Time:      1:00pm - 2:00pm, Friday, March 25, 2016 Date & Time:      5:00pm - 6:00pm, Thursday, April 7, 2016 Date & Time:      5:00pm - 6:00pm, Wednesday, April 27, 2016 Enhance your Library Skills Description:      Are you new to the Medical Campus? Need a refresher on how to use the Medical Library?  Information experts will assist you in finding everything from books in the online catalog to locating peer-reviewed full-text articles including when and how to request materials through our Interlibrary Loan service. You will be surprised about the resources and services available to you. Use the library catalog to find materials including books, prints, maps, and more Decipher confusing citations Find full-text articles Identify article databases in your subject area Distinguish when and how to request material through Interlibrary Loan Identify your librarian Date & Time:      2:00pm - 2:50pm, Thursday, January 28, 2016 Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Tools for gene enrichment analysis Description:                        Bioinformatics enrichment tools play an important role in identifying, annotating, and functionally analyzing large list of genes generated by high-throughput technologies (e.g. microarrary, RNA-seq, ChIP-chip). This workshop will provide an overview of the principle, type of enrichments, and the infrastructure of enrichment tools. By using concrete examples, it will also introduce some of the most popular tools for gene enrichment analysis such as DAVID, GSEA, and WebGestalt, as well as the proprietary softeare MetaCore. Date & Time:      12:00pm - 1:30pm, Thursday, February 4, 2016 Location:              SHM L Simbonis Room 101A Yale Medical Library, 333 Cedar St. New Haven CT 06520   Systematic Reviews: Conducting comprehensive searches Description:        One critical step in the SR process is to comprehensively search the literature. This workshop will introduce procedures to ensure that your search is comprehensive, methodical, transparent and reproducible. Date & Time:      1:30pm - 3:00pm, Wednesday, February 10, 2016 Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520   The VERY Basics of the Unix Command Line Description:        A lot of biomedical software programs do not come with a graphical user interface (GUI), and a Unix command-line terminal environment is required to run such programs. In this 2-hour session, you will learn the basics of a Unix command-line terminal, such as how to navigate the file system, the permission and security structure, and how to run programs from the command line. No previous Unix or command-line experience is required to attend this session. Free and open to any Yale University student, faculty and staff.  Registration required since the number of seats is limited. Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Date & Time:      2:00pm - 4:00pm, Thursday, February 11, 2016 Date & Time:      10:00am - 12:00pm, Thursday, April 14, 2016 Introduction to patents and patent searching Description:        Patents are challenging but important sources for product development and discovery of technical information. This workshop will provide a basic introduction to the patent literature and the United States patent process. We will look at tools and strategies for locating patents and intellectual property. Date & Time:      2:00pm - 3:00pm, Friday, February 19, 2016 Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520   Introduction to Genome Browsers Description:        In this workshop we will learn how to navigate the genome browsers from NCBI's Genome Workbench, UCSC Genome Browser, and Ensembl. These browsers are valuable tools when identifying, localizing genes, and looking at their information in the genomic context. By using concrete examples, it will be shown how to locate a human gene, download a gene sequence and its upstream sequence, locate Single Nucleotide Polymorphisms (SNPs) and conserved regions, and use the browsers to download results in a batch Date & Time:      12:00pm - 1:30pm, Thursday, February 25, 2016 Location:              Medical Library, Simbonis Large Conference Room 101A, 333 Cedar St, New Haven CT 06520   Cytoscape: Going from Raw Data to a Publishable Image Description:        These hands-on workshops will demonstrate the use of Cytoscape, an open source molecular interactions visualization tool. Cytoscape allows for the exploration of molecular interactions and biological pathways and integrates these networks with annotations, gene expression profiles, and other data.  One session, “Cytoscape:  Going from Raw Data to a Publishable Image,” will cover core functions, such as learning how to import network and attribute data, change visual properties to easily distinguish biologically significant relationships, create a legend for the image, manually add nodes/edges, etc. Date & Time:      9:00am - 12:00pm, Thursday, March 3, 2016 Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520 Presenter:          Marci Brandeburg, University of Michigan.   Cytoscape apps with a Focus on MetScape Description:        This hands-on workshop will provide an introduction to Cytoscape apps, which add functionality to the core software.  It will focus on a specific app example, MetScape, which is used to visualize and interpret metabolomics and gene expression data in the context of human metabolic networks.  A brief introduction to other apps, such as MCODE (cluster finding tool), SocialNetwork (builds co-publication networks), and MetDisease (annotates metabolic networks with MeSH disease terms) will be included. Date & Time:      1:30pm - 4:00pm, Thursday, March 3, 2016 Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520 Presenter:          Marci Brandeburg, University of Michigan   BioMart: A Research Data Management Tool for the Biomedical Sciences Description:        Some complex biomedical questions cannot be answered by reading the published literature. These may require aggregation of data from several data sets. In this regard, BioMart (www.biomart.org) is a freely available open source system that allows complex queries across more than 40 different biological data sets through a single web interface. Originally developed for the Ensembl genome browser, BioMart has been integrated into widely used software such as Galaxy, BioConductor, and Cytoskape. The BioMart interface is also used by data portals such as Ensembl, Wormbase, Gramene, and Reactome. In this workshop we will use simple examples to demonstrate how to navigate, build queries, and save and export the results on BioMart such as: - how to retrieve the Ensembl mouse genes and genomic locations in the first 10 Mbp of chromosome 1 region; - retrieving 1 kb of upstream sequences from a cluster of human genes identified by an expression profile experiment; - obtain a list of the SNPs that have been associated with RB1. For the SNPs, obtain several attributes such as source, rs ID, chromosome location, and pathogenicity   Date & Time:      12:00pm - 1:30pm, Thursday, March 10, 2016 Location:              Medical Library, Simbonis Large Conference Room 101A, 333 Cedar St, New Haven CT 06520 Presenter:          Rolando Milian   Novel Online Tools for Mining the Biomedical Literature   The rapid growth of experimental and computational biomedical data is being accompanied by an increase in the number of biomedical publications discussing these results. This makes retrieving relevant scientific information and identifying connections between findings, a challenging task. New literature-mining tools that make use of Natural Language Processing Algorithms and data visualization (e.g. CoreMine, NextBio, Semantic MEDLINE, etc) may be of help when sorting through this abundance of literature as discovery and hypothesis generating tools. This workshop provides an introduction on how to use some of these literature-mining tools when answering research questions and generating/narrowing hypothesis. Date:     Thursday, March 24, 2016 Time:     12:00pm - 1:30pm Location:              Cushing/Whitney Medical Library at Yale University, Simbonis Conference Room 101A, 333 Cedar St, New Presenter:          Rolando Milian   My Bibliography and SciENcv: grant reporting, compliance and biosketch through MyNCBI Description:        Although not required at this point, the NIH suggest the use of the Science Experts Network Curriculum Vitae (SciENcv), -a MyNCBI online tool- that serves as an interagency system designed to create biosketches for multiple federal agencies. This, along with the use of My Bibliography for grant activity reporting and NIH Public Access Policy compliance, increases the importance using MyNCBI as a tool for managing NIH-sponsored research. This workshop introduce researchers, research assistants and administrators on the effective use of these online tools and will cover the following among other topics: How to create MyNCBI account and how to link it to the eRA Commons account How to delegate your account  How to populate and manage My Bibliography How to use My Bibliography for grant reporting/compliance How to use SciENcv to create different biosketches (from scratch, from external source, etc) How to create and ORCID ID* and how to link SciENcv to that ORCID ID   *ORCID stands for Open Research and Contribution ID. Some publishers and journals (Springer, Wiley, Journal of Neuroscience, The Journal of Immunology, etc.) are asking authors to submit their ORCD ID along with their manuscripts for publication.   Date & Time:      12:00pm - 1:00pm, Thursday, April 21, 2016 Location:              Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Presenter:          Rolando Milian

Cushing/Whitney Medical Library 75th Anniversary Kickoff

January 25, 2016 - 4:23pm by Andy Hickner

(by Janene Batten) Over the course of 2016, the Cushing/Whitney Medical Library will be celebrating 75 years since its founding.   The Medical Library’s anniversary kick-off event on Friday was a great success. Harvey Cushing himself made a special appearance. He was available for photographs with everyone, including these 3 students. Everyone enjoyed the cake, which featured the Library’s 75th logo.  The Library has also begun to collect audio snippets of people's recollections of the Library. We will soon begin to update the library's Facebook page with these stories. You are welcome to attend any of the variety of 75th Anniversary Events which are open to our patrons and friends. If you have a special memory, please share your story . And as the year progresses, come back and read the impact that the Library has had on others.

Call for donations of Second Year Show videos/DVDs

January 25, 2016 - 11:48am by Andy Hickner

The Medical Historical Library is looking for videos/DVDs for the Medical School’s Second Year Shows.  We tend to get requests for the shows on at least yearly, when the current Second Year Show is in production. While we have some of the shows, we don’t own the last few years (2011-2015) and very little before 2005.  If you own a Second Year show, please considering donating (or allowing us to make copies) of the show for our Archives.  
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