Blogs

The Yale Medical Library is providing to all Yale affiliates free access to two of the most powerful commercial bioinformatics tools for the analysis of omics data: MetaCore and Ingenuity Pathway Analysis. This is part of a pilot project conducted by the medical library in order to find sustainable and long term access to these tools. Please register for these upcoming trainings if you are interested in learning how to use these tools or if you need a refresher. For questions on how to register for an account or comments please contact Rolando Milian Title: Introduction to Ingenuity Pathway Analysis Description: What is IPA and what questions can it address? Overview of key features in IPA Ingenuity Knowledge Base Search & Pathway Building - Gene/ Chemical, Functions, Drug Targets Advanced Search: Limiting results to a molecule type, family or disease-association. Building pathways: Creating a pathway, pathway navigating, Using Build and Overlay tools Bioprofiler Dataset Analysis: Interpretation of Gene, Transcript, Protein and Metabolite Data Data Upload and Analysis:  Uploading and formatting a dataset, setting analysis parameters and running an analysis Pathway Analysis and Canonical Pathways Downstream Effects Analysis and identifying downstream functions and processes that are likely affected Upstream regulators Analysis Causal Network Analysis and identifying likely root regulators Regulator Effects Analysis to link upstream regulators with downstream functions and processes that are affected Comparison analysis and comparing multiple observations Date & Time:      9:00am - 12:00pm, Tuesday, October 27, 2015 Location:              H-203, Jane Ellen Hope Building, 315 Cedar St, New Haven CT Presenter:          Field Scientist QIAGEN Informatics   Title:      MetaCore: Getting the most from your "omics" analysis (Introductory session) Description: The ability to generate massive amounts of data with "omics" analysis begs the need for a tool to analyze and prioritize the biological relevance of this information. GeneGo provides a solution for using "omics" gene lists to generate and prioritize hypotheses with MetaCore. This tutorial highlights how to work with different types of data (genomics, proteomics, metabolomics and interaction data) beginning with how to upload gene lists and expression data (if available). Here we demonstrate data manager capabilities including how to upload, batch upload, store, share and check data properties and signal distribution. We then focus on how MetaCore uses your gene list to extract functional relevance by determining the most enriched processes across several ontologies. This entails a detailed lesson on how to prioritize your hypothesis using the statistically significance enrichment histograms and associate highly interactive GeneGo Maps and pre-built networks. We further emphasize the role of expression data in your analysis and the ability to visually predict experimental results, associated disease and possible drug targets. Lastly we highlight the benefits of using MetaCore workflows to compare data sets and work with experiment intersections. Date & Time:      10:00am - 12:00pm, Tuesday, November 3, 2015 Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520 Presenter:          Dr. Matthew Wampole, Solution Scientist, IP & Science, Thomson Reuters   Title:      MetaCore: Getting the most from your "omics" analysis (Advanced) Description: In the advanced tutorial, we will explore uses of our network building algorithms and methods for hypothesizing key hubs passed on data. We will begin this session with a discussion on using the Key Pathway Advisor to hypothesize key hubs regulating gene expression data. The session will then review ways of using the 11 network building algorithms in MetaCore. The first example will review how to build a network purely from the curated knowledge within MetaCore. Then we will go through an example of using omics data to build a network of interactions to better understand the relationships within our data. Date & Time:      1:00pm - 3:00pm, Tuesday, November 3, 2015 Location:              C-103 - SHM 333 Cedar St, New Haven CT 06520 Presenter:          Dr. Matthew Wampole, Solution Scientist, IP & Science, Thomson Reuters     Join the End-user Bioinformatics Group and become a member of a community that collaborates on end-user bioinformatics events, training sessions, resources, and tools that support biomedical research at Yale.

(Post authored by Melissa Grafe) The Medical Historical Library announces a new gift encompassing visual materials depicting medical practice, public health, disease, and more from the collection of Bert Hansen, Ph.D. Over a period of thirty years, Bert Hansen actively collected original materials to document and exhibit the visual record of public health and medical practice and research in America, primarily in graphics published in popular media.  Hansen has been teaching history at Baruch College of CUNY since 1994. He holds degrees in chemistry (Columbia) and history of science (Princeton).  Prof. Hansen has written on obstetrics teaching in the 1860s, the new medical categorization of homosexuals in the 1890s, the advocacy for public health and sanitation in political cartoons from 1860 to 1900, and the popularity of medical history heroes in children’s comic books.  His book, Picturing Medical Progress from Pasteur to Polio: A History of Mass Media Images and Popular Attitudes in America (Rutgers University Press, 2009), was honored with an award from the Popular Culture Association and named to the “2010 Best of the Best” for Public and Secondary School Libraries by the American Library Association. Recently, Hansen began transferring his collection to the Medical Historical Library.  The library was given over 600 prints, including chromolithographs and wood engravings from 19th-century magazines like Harper’s Weekly, Frank Leslie’s, Puck, and Judge.  Hansen also donated 20th-century popular magazines such as Life and Time, which reported on medical issues.  LIFE magazine published serious photographic essays about medical subjects on a regular basis, at least 1100 of them in its 1900 weekly issues.  Because few libraries have preserved this magazine, Hansen collected several hundred issues with medical stories to document the way the mid-20th century public was taken into operating room, the laboratory, and the mental asylum. For Hansen, the central research question animating the collection was:  Just what did medicine look like to the average person (not to the insiders within the profession)?  All the images were collected to answer that question.  In addition to news sketches in magazines like Harper’s Weekly, political cartoons turned out to be a remarkable source of visual evidence.  Medicine itself was rarely the object of the caricature, but when a president is shown as a doctor looking through a microscope or amputating a limb, or portrayed as a midwife with forceps or a nurse tending to a patient in bed, we get a sense of stereotypes and popular expectations.  Despite comic exaggerations, these images had to be sufficiently true-to-life for the political message to be understood. Hansen has also donated a small collection of manuscripts, which includes diaries, notebooks, casebooks, and scrapbooks by medical practitioners or on medical themes.  Future parts of the gift will include hundreds of examples of ephemera, from agencies such as health departments and corporations like Met Life, all of which used graphics to convey their messages to the public.  There will also be publicity materials for radio broadcasts and Hollywood films about physicians.  The collection also includes about two dozen highly illustrated juvenile biographies of physicians, and over 100 medically themed comic books.  In addition to the unique original materials, Hansen’s collection contains about ninety 3-ring binders containing photocopies of relevant images (both those in the collection and others that are not).  All the items in the binders and in the collection of originals are recorded in a database with over 4500 entries, which can be searched by keyword, publication, genre, medium, artist, date, etc., and will be made available at a future date. For questions concerning the collection, please contact Melissa Grafe, Ph.D, John R. Bumstead Librarian for Medical History: melissa.grafe@yale.edu

The Medical Library is hosting 2 events for Founder's Day, this Wednesday, Otober 7.   From 11-3 we will offer tours featuring the Cushing Center and our current exhibit, Historical Illustrations of Skin Disease. We will also have a visit from our therapy dog, Finn, from 11am-noon. For more info visit https://secretary.yale.edu/university-events

Starting Monday, October 5th, 2015 the Cushing/Whitney Medical Library will be opening at 7:30 am Monday through Friday! Sun and Moon, Hartmann Schedel's Nuremberg Chronicle, 1493

The Medical Library's Digital Collections will undergo scheduled maintenance from 7:30am-noon on Wednesday, September 23.  During that time, they will be unavailable.  We apologize for any inconvenience.