Blogs

Contest Winners for "Discovering the Beauty of Science"

13 January 2016 - 4:08pm by Andy Hickner

(by Rolando Garcia Milian and Terry Dagradi)

Last summer we invited Yale biomedical researchers (undergrads, graduate students, postdocs, faculty, associate researchers, etc.) to share results from their work where they felt the images produced in search of science crossed over to art.  We thank all of you who submitted and appreciate your willingness to share with the community. 

The images were reviewed by a committee including New Haven sculptor Gar Waterman, Sarah Fritchey (Curator / Gallery Director at Artspace New Haven), and Dr. Derek K. Toomre, Associate Professor of Cell Biology and Director of the YALE 'CINEMA’ Laboratory. Together, they selected many of the images currently on exhibit in the foyer of Cushing/Whitney Medical Library as well as the three 1st Honor awardees.

The 1st Honor Awardees are:

Marco Onorati, Department of Neurobiology

Neurons in a Dish, 2015

Juror comments: “Neuron: Good rendition, dreamy quality”  “The fantastic crystalline structure in the center of this composition is very powerful. The sense of pull and energy is so forceful that it almost suggests a big bang moment.”

Neurons in a Dish

(Click to view larger image)

Neurons differentiated in a dish from stem cells.  Microphotograph, fluorescence. 

 


Mustafa Khokha, Department of Pediatrics

Frog Head, Year: 2015

Juror comments: “Great composition and detail.”  “Just a cool thing, whatever it is”

Frog head

(Click to view larger image)

Xenopus laevis tadpole (frog). Brain (green) and Actin (red) and nuclei (blue) View from the back of the head over the Imaged with Leica Sp8 Confocal by Helen Rankin Xenopus Cold Spring Harbor Course.

 

Kate Henderson, Department of Pathology

Stones Dreaming, 2013

Juror comment: “My favorite - love this one - fabulous color and pattern”

Stones dreaming

(Click to view larger image)

Abstract digital composition of microscopy endocrine images.

Image description: I create environments from natural elements to give people a sense of place, describing emotional essence and energy that connects us to each other and everything around us. My images both describe and celebrate the intrinsically aesthetic structure of the natural world and the ever-present duality in all things. I invite the viewer to see and feel the world both within us and around us, experiencing the macro vs microelements common to all.

Painting-with-cells is how I describe the cyto-Illusions series. I start by using microscope images of human cells and also images of abstraction “found” in nature. Through layering and manipulation techniques, I create an image that mirrors micro images on a macro level. On one level the images are a colorful abstraction that allow the viewer to freely explore and experience the image on their own. Many images are suggestive of a specific element such as water, but others are more environmentally placed. On another level the images are about the reality of nature; cells of disease, the growth structure of plants, and the patterns of light filtered through the leaves.

 

The Viewers’ Choice Award

This was determined by all those who voted (404 votes total) on an exhibition album created on the Medical Library Facebook page.

Laura Pappalardo – Department of Neurology

Astrocytes display robust intracellular calcium response in model of astrogliosis, 2013

Astrocytes

(Click to view larger image)

Astrocytes, a non-neuronal type of cell in the brain and spinal cord, respond to central nervous system insult through the incompletely understood process of reactive astrogliosis, which is a hallmark in pathologies such as multiple sclerosis and spinal cord injury. While the ramifications of astrogliosis are debated, it is agreed that in its extreme forms, this process leads to the formation of a scar, which is long-lasting and can inhibit the regeneration of injured neurons. While the molecular drivers of astrogliosis are an area of active investigation, a clearer understanding is needed. Here, we show that after a scratch injury, there is a robust intracellular calcium response, which propagates through the syncytium of confluent astrocytes (red indicates high intracellular calcium). This calcium transient leads to downstream signaling that can regulate the astroglial response to injury. We are currently working to investigate the mechanisms behind this phenomenon, paying particular attention to voltage-gated sodium channels.

Color scale represents the ratio of fluorescent signals induced by 340 and 380 nm excitation in cells loaded with Fura-2 AM. Scale bar, 50 ╡m. In collaboration with Stephen Waxman, Joel Black, Mark Estacion, and Omar Samad.

The Cushing/Whitney Medical Library celebrates 75 years

13 January 2016 - 2:04pm by Andy Hickner

Medical Library Rotunda

Join us as the Cushing/Whitney Medical Library celebrates 75 years of being YOUR library. We are planning a year long program of exciting events. Mark your calendar for these highlights and watch for additional events, exhibits and information.

January 22, 2016, 3-5pm
75th Anniversary Kickoff Party

April 6, 2016, 4pm
Associates Lecture and Reception, Immune system in health and disease. Dr. Ruslan Medzhitov

June 3, 2016, 3pm
Special Presentation, Harvey Cushing and John Fulton: Two Icons of the Roaring Twenties Bonded by Medicine and Books.  Dr. Dennis D. Spencer and Dr. Gordon Shepherd

October 5, 2016, 3-5pm
75th Anniversary Gala

http://library.medicine.yale.edu/75

Beaumont Club Lecture on "Historical Illustrations of Skin Disease" Exhibit, Friday, January 15

12 January 2016 - 10:35am by Andy Hickner

Skin disease lecture

On Friday 1/15 at 5pm, the Beaumont Club is sponsoring a lecture about the Library's exhibit “Historical Illustrations of Skin Disease: Selections from the New Sydenham Society Atlas 1860-1884.”  The lecture will be given by Jean Bolognia, MD, and Irwin Braverman, MD, both of the Department of Dermatology, and Susan Wheeler, Curator of Prints and Drawings at the Medical Library. More details are available on the School of Medicine calendar.

What's a guide? And how can Yale library guides help me?

11 January 2016 - 3:12pm by Andy Hickner

Librarians at Yale have developed numerous online guides for Yale users.  Here at Yale, our guides can provide a number of things, including:

  • Research guidance for a particular Yale course;
  • Instructions on how to research a subject;
  • Documentation for a research tool or service; or
  • Instructions on accessing and using collections or resources.

You might find different guides of particular interest based on your role and field, for example:

Get started exploring our full list of guides in the field of medicine, or browse all Yale guides including on topics outside the health sciences. 

DatabasE of genomiC varIation and Phenotype in Humans using Ensembl Resources (DECIPHER)

6 January 2016 - 1:41pm by Rolando Garcia-Milian

Many genetic variants are novel or rare which makes difficult their clinical interpretation. The DECIPHER Consortium was initiated in 2004 as a community of academic centers of Clinical Genetics who submit consented, anonymized  genotype  and  phenotype  data  from  patients  with  rare  genomic  disorders for sharing with other clinicians and researchers. The identification of patients sharing variants in a given locus with common phenotypic features leads to greater certainty in the clinical interpretation of these variants. As of January 6, 2015, there are 18 539 publicly available patient record, 51 496 phenotype observation in these patients, and 27 175 publicly available copy-number variants in this database.

DECIPHER can be search by phenotype, by genomic position, band, gene, pathogenicity, variant consequence, etc. Results are presented as a table or can be visualized in a browser. This browser contains different tracks where variants can be visualized in the context of other data.

Learn more on DECIPHER and how to use it to make sense of genetic variants at the workshop “Making Sense of Variation”. Please register here if you would like to attend.

You can also contact Rolando Garcia-Milian with questions on this or any other variation tool,

References

DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources. Firth, H.V. et al (2009). Am.J.Hum.Genet 84, 524-533 (DOI: dx.doi.org/10/1016/j.ajhg.2009.03.010)

Exhibit: "Deaf: Cultures and Communication, 1600 to the Present"

6 January 2016 - 12:20pm by Andy Hickner

Deafness exhibit

What is deafness? From a medical perspective, deafness is an audiological condition that might be resolved through hearing aids or cochlear implants. But from another perspective, to be Deaf (often spelled with a capital “D”) is to belong to a culture, with a shared language and identity. This exhibit explores how people have understood deaf communication and Deaf culture since the seventeenth century, with displays on the history of education, medical interventions, sign languages, and popular culture.

This exhibit runs Thursday, January 21, 2016 - Friday, April 1, 2016.

Additional events include:

For a list of upcoming events, please visit the exhibit page at http://library.medicine.yale.edu/historical/deaf.

Qualtrics, an online survey tool

21 December 2015 - 5:48pm by Andy Hickner

(by Denise Hersey)

If you need to create a survey as part of your research, you now have access to Qualtrics, an online survey tool which is HIPPA-compliant.  Qualtrics allows you to create surveys with a myriad of different question types and report options.  You can also collaborate on surveys with colleagues at Yale and share results and data.  Qualtrics is easy to use, but Yale medical librarians can also provide you with support.  

Qualtrics

YSM theses now available through EliScholar

15 December 2015 - 11:37am by Andy Hickner

(by Nathan Rupp and Melissa Grafe)

Nearly 900 Yale School of Medicine theses are now available through Yale University’s online institutional repository known as EliScholar. These include “current” theses published in the last decade that have come out of embargo as well as several YSM alumni theses published as far back as 1952. These theses document the rich research done by Yale’s medical students, and can provide a starting point for current medical students embarking on their projects.  We’re also pleased to make this part of our collection more openly accessible to researchers in general, as the print theses are stored in locked stacks at the Medical Library.  Current YSM students can browse this collection for examples of what a YSM thesis looks like.

For more information about accessing theses at the Medical Library, please see http://library.medicine.yale.edu/find/thesis.

If you are an alumnus and want your thesis digitized, complete this form and email it to Nathan Rupp at nathan.rupp@yale.edu

Yale Physician Associate Program recognizes 3 librarians

10 December 2015 - 12:35pm by Andy Hickner

Jan, Judy & Lei with PA award

From left: Lei Wang, Judy Spak, Jan Glover

On December 7, the Yale Physician Associate Program recognized librarians Jan Glover, Judy Spak, and Lei Wang "for their support & dedication to the thesis & student research."  Each year, these librarians work intensively with students in helping define their thesis statement, and then guiding and assisting them as they conduct the necessary research and literature review. Congratulations, Jan, Judy, and Lei!

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