Blogs

There will be an interruption of service for Elsevier platforms and solutions due to scheduled maintenance. On Saturday, August 1, access to Elsevier platforms will be unavailable due to a scheduled maintenance for approximately 4.5 hours starting at 06:00 PM EST.  The platforms and solutions involved are: Elsevier Research Platforms: ScienceDirect, Scopus (including Author Feedback Wizard), Engineering Village, Mendeley Research Intelligence: SciVal Funding R&D Solutions: Reaxys, Embase, Geofacets To stay up to date with any developments, follow the individual Twitter accounts for the products.

The Medical Historical Library is now on Instagram!  Charlotte Abney, one of our student workers and a graduate student in the Program in the History of Medicine, is the force behind the account.  We’re also on Twitter (@YaleMedHisLib) and experimenting with Pinterest.  

(By Melissa Grafe) You can now request locked Medical Historical Library books through Orbis, instead of emailing staff at the Historical Library.  Please do this when you want access to our locked stacks materials, for use in our Historical Library Office/reading room, or any events, sessions, or classes that you may be holding.  For classes or other events, please email Melissa Grafe at melissa.grafe@yale.edu to discuss scheduling and support. From Orbis, in the Holdings area: The first time you “Request for Use in the Medical Historical Library,”  you will be prompted to register, unless you’ve already registered as a patron at Beinecke or Manuscripts and Archives.  After that, the information will automatically populate in the form. Just put in what date you are planning to come to the Medical Historical Office to view the materials, and Submit the request!   We may have to take your photograph and check your Yale ID, even if we know you, as part of joining this system with Beinecke/Manuscripts and Archives and updated security protocols. Within the next few months we will expand the ability to request materials from the Medical Historical Library’s finding aids, which you can discover in the Yale Finding Aid database. The finding aids are lists, usually down to the folder level, from our archival collections, including the papers of doctors, our medically themed sheet music collection, and the William Van Duyn tobacco advertising collection.

Introduction to Ingenuity Pathway Analysis Description:     What is IPA and what questions can it address? Overview of key features in IPA Ingenuity Knowledge Base Search & Pathway Building - Gene/ Chemical, Functions, Drug Targets Advanced Search: Limiting results to a molecule type, family or disease-association. Building pathways: Creating a pathway, pathway navigating, Using Build and Overlay tools Bioprofiler Dataset Analysis: Interpretation of Gene, Transcript, Protein and Metabolite Data Data Upload and Analysis:  Uploading and formatting a dataset, setting analysis parameters and running an analysis Pathway Analysis and Canonical Pathways Downstream Effects Analysis and identifying downstream functions and processes that are likely affected Upstream regulators Analysis Causal Network Analysis and identifying likely root regulators Regulator Effects Analysis to link upstream regulators with downstream functions and processes that are affected Comparison analysis and comparing multiple observations Date & Time:  9:00am - 12:00pm, Wednesday, July 15, 2015 Location:         C-103 333 Cedar St, New Haven CT 06520 Campus:          Medical School Presenter:       Dr. Kate Wendelsdorf, Applied Advanced Genomics, QIAGEN Informatics   Advance Ingenuity Pathway Training: Integrated Analysis and Interpretation of Variant and Gene Expression Data from Breast Cancer Subtypes             Methods that jointly interpret genomes and transcriptome data from disease case samples may be able to identify disease-specific factors and pathogenicity mechanisms that may not be observable on a single data type. These insights can then be used create more effective screenings or treatments. Here we show how jointly analyzing tumor-specific genotypes and gene expression can indicate medically important differences among tumor subtypes. Pairing two tools from Ingenuity® Systems – Variant Analysis  (for interpreting human genome data) and IPA® (for transcriptome data) – we trace differences between breast tumors that spread quickly (Claudin-low) versus slowly (luminal) to sequence variation that likely governs Epithelial-to-Mesenchymal Transition (EMT). Variant Analysis was used to filter genomic variants in RNA seq data to a shortlist of those plausibly involved in driving tumor spread. IPA is then used to leverage gene expression patterns from the same dataset to identify molecular pathways involved in the metastatic phenotype of Claudin-low breast cancers. The seminar will demonstrate how using a combination of IPA features and QIAGEN tools can provide insight in to phenotype-causing pathways for experimental follow-up and hypothesis testing. Date & Time:  1:00pm - 4:00pm, Wednesday, July 15, 2015 Location:         C-103 333 Cedar St, New Haven CT 06520 Campus:          Medical School Presenter:       Dr. Wendelsdorf- QUIAGEN Category:        Bioinformatics     Managing your References with EndNote Description:     EndNote is a citation-management software application that makes saving citations and then citing them within documents easy. EndNote's pre-formatted style templates, specific to journal instructions, make it easy to insert references into your papers as you write them. In this class you will learn how to easily add citations into your EndNote library, attach PDFs, and insert references into your research papers. Date & Time:  2:00pm - 3:00pm, Wednesday, July 29, 2015 Location:         Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Campus:          Medical School Presenter:       Denise Hersey Category:        Reference Management Systems   Give your PubMed Skills a Tune Up Description:     PubMed is one of the most comprehensive resources for searching the biomedical literature.  Most researchers have used it one time or another, but it may be time to brush up on your search skills to ensure that you have a relevant set of results.  In this class, we will go over PubMed search techniques, including how to quickly limit a search and the role of Medical Subject Headings (MeSH) in creating more effective searches. Participants will also learn time-saving features such as saving searches and how to link out to full-text. Date & Time:  6:00pm - 7:00pm, Wednesday, July 29, 2015 Location:         Medical Library, Room 103 TCC, 333 Cedar St, New Haven CT 06520 Campus:          Medical School Presenter:       Melissa Funaro Category:        Reference Management Systems     Webinar: Introduction to Cytoscape: network visualization software Description:     Cytoscape, an open source molecular interactions visualization tool, allows the exploration of molecular interactions and biological pathways and integrates these networks with annotations, gene expression profiles, and other data.  This webinar will provide an introduction to some of the core functionality of Cytoscape, including the loading and manipulation of experimental data.  For example, you will learn how to change visual properties to easily distinguish biologically significant relationships.  Many additional features and advanced analyses are available through Cytoscape’s extensive list of apps. Examples of apps are MetScape (allows for visualizing and interpreting metabolomic data), Reactome FI (Reactome Functional Interaction and pathway enrichment tool), and BiNGO (Gene Ontology Tool). Date & Time:  11:30am - 12:30pm, Tuesday, August 11, 2015 Location:         Medical Library, Large Conference Room 101A, 333 Cedar St, New Haven CT 06520 Campus:          Medical School Presenter:       Marci Brandenburg, Bioinformationist, Taubman Health Sciences Library, University of Michigan Category:        Bioinformatics  

The Medical Historical Library has recently acquired a collection of twenty-nine posters and digital works on themes of social justice and health care by artist/activist Rachael Romero.  Many works date from 1975 to 1982 and were created by Ms. Romero for the San Francisco Poster Brigade which she co-founded.   Originally displayed on city streets—often on the sides of buildings—the posters bear messages such as “Decent Housing is a Basic Right.” and “Preventive Medicine, Not Costly Operations.” Documented in the collection is “The Fight for the International Hotel,” which became a local cause cèlébre in 1976-78 when the hotel which provided low cost accommodations and community was threatened by, and subsequently razed for, development.  Two recent original digital works reflect Ms. Romero’s personal odyssey through diagnosis and treatment of a brain tumor.